The musculoskeletal manifestations of Werner's syndrome.
نویسندگان
چکیده
Werner's syndrome is a rare condition usually presenting as premature ageing in adults. Over a period of 30 years we have followed two siblings with extensive musculoskeletal manifestations including a soft-tissue tumour, insufficiency fractures, nonunion and tendonitis, with associated problems of management. The literature is reviewed.
منابع مشابه
LMNA mutations in atypical Werner's syndrome.
BACKGROUND Werner's syndrome is a progeroid syndrome caused by mutations at the WRN helicase locus. Some features of this disorder are also present in laminopathies caused by mutant LMNA encoding nuclear lamin A/C. Because of this similarity, we sequenced LMNA in individuals with atypical Werner's syndrome (wild-type WRN). METHODS Of 129 index patients referred to our international registry f...
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عنوان ژورنال:
- The Journal of bone and joint surgery. British volume
دوره 82 6 شماره
صفحات -
تاریخ انتشار 2000